Overview

Original Research

EFFECT OF MENSTRUAL CYCLE LENGTH ON LIPID PROFILE AND INFLAMMATION IN HEALTHY INDIAN WOMEN

SHILPI VASHISHTA 1, MANISH KUMAR 2, SHILPI BHAT 3, SHOBITHA MUTHUKRISHNAN 4, and SUSHILA GAHLOT 5.

Vol 18, No 11 ( 2023 )   |  DOI: 10.5281/zenodo.10153215   |   Author Affiliation: Assistant Professor, Department of Physiology, School of Medical, Sciences & Research, Sharda University, Greater Noida, Uttar Pradesh, India 1; Assistant Professor, Department of Physiology, School of Medical, Sciences & Research, Sharda University, Greater Noida, Uttar Pradesh, India 2; Senior Tutor, Department of Physiology , School of Medical Sciences & Research, Sharda University, Greater Noida, Uttar Pradesh, India 3; Professor and Head, Department of Physiology , School of Medical Sciences & Research, Sharda University, Greater Noida, Uttar Pradesh, India 4; Ex-Professor and Head, Department of Physiology Gian Sagar Medical College and Hospital, Patiala, Punjab 5.   |   Licensing: CC 4.0   |   Pg no: 364-371   |   Published on: 18-11-2023

Abstract

Introduction - Several studies show that variations in the length of the menstrual cycle significantly affect lipid and CRP parameters. There is acute paucity of literature comparing lipid profiles and CRP in women with short and prolonged menstrual cycle length in absence of PCOD and other gynecological conditions. The aim of this study was to establish menstrual cycle length as the simplest tool to predict cardiovascular risk. Objective- To determine menstrual cycle length and its relationship with lipid profile and CRP. Method -The association of lipid and CRP parameters with menstrual cycle length was evaluated in 337 women aged 15-45 years. Based on a questionnaire about menstrual bleeding, participants were divided into three groups: women with short, normal and long menstrual cycles. A menstrual cycle length of 24-38 days was considered normal. Lipid profile and CRP were analyzed during the menstrual cycle in women with short normal and prolonged cycles, and the results were statistically analyzed. Results – Mean levels of cholesterol, triglycerides, LDL, VLDL, lipid ratio and CRP were increased in women with short and long menstrual cycles compared to women with normal menstrual cycles, and this increase was significant for TC, TG, VLDL and TC/HDL and TG/HDL ratios, while HDL was significantly lower (P<0.05). Conclusion - Women with short and long menstrual cycles have a higher risk of developing cardiovascular disease in the coming years compared to women with normal menstrual cycle length.

Keywords

Lipid; Cardiovascular Disease; Predictor; Regularly Menstrual Cycle Length, Short Menstrual Cycle Length, Prolonged Menstrual Cycle Length; C-Reactive Proteins