"THE EVALUATION OF SAFETY PERTAINING TO THERMAL AND REACTION PROCESSES IN THE PHARMACEUTICAL INDUSTRY"
Process Safety is study of hazards & managing risks that are involved in any type of Chemical reactions that are occurring at an industrial level. It is a step-by-step review of industrial operating procedures where it is undertaken to identify the potential causes (parameters like temperature, pressure, concentrations of reactants) and possible consequences of hazardous chemical releases. In our project we are using RSD (Rapid Screening Device) systems of Thermal Hazard Technology (THT) which help in the determination of optimum temperature for a particular reaction to take place & decomposition rate. Using a reference sample, we try to devise the operatable temperature range for production, for our desired samples loaded in the RSD. The 6 samples used here are A, B, C, D, E, F along with the reference sample are tested are 20,30,40,50,60° C at regular time intervals to calculate the Decomposition rate. The graphs generated for Temperature Vs. time & Pressure are analyzed for the creating the process safety data analysis at production scale. Advance to this RSD the Thermal Hazard Technology Introduced ARC (Accelerating rate calorimeter). The ARC has specific features and advantages that make it unique and preferable to all other technologies that were available at this time - and today 30 years later this technology is still the number one choice for most people focusing in the area of quantifying exothermic reactions, effect of heat upon materials and simulating runaway reactions.