Overview

Original Research

THE ROLE OF PRO-INFLAMMATORY CYTOKINES IN VARIOUS TYPES OF SYSTEMIC SCLERODERMA

ARIPOVA N.А 1, DJURAYEVA E.R 2, ABDUAZIZOVA N.X 3, BERDIYEVA D.U 4, GANIYEVA N.A 5, and ZIYAYEVA F. K 6.

Vol 18, No 06 ( 2023 )   |  DOI: 10.17605/OSF.IO/XAMQJ   |   Author Affiliation: Assistant of Department of faculty and Hospital Therapy No1 with Course of Professional Pathology of Tashkent Medical Academy of Uzbekistan 1,5; Ph.D, Associate Professor of Department of Faculty and Hospital Therapy No1 with Course of Professional pathology of Tashkent Medical Academy of Uzbekistan 2,3; Ph.D, Assistant of Department of Faculty and Hospital Therapy No1 with Course of Professional Pathology of Tashkent Medical Academy of Uzbekistan 4; Senior Lecturer of Department of Faculty and Hospital Therapy No1 with Course of Professional Pathology of Tashkent Medical Academy of Uzbekistan 6.   |   Licensing: CC 4.0   |   Pg no: 1469-1476   |   Published on: 27-06-2023

Abstract

Purpose of the study. To study the relationship between the serum level of interleukin-4 (IL-4) and visceral pathology, the nature of the course and clinical forms of SS. Materials and methods. IL-4 was determined in the sera of 60 patients with SS by indirect enzyme-linked immunosorbent assay. Results. The level of IL-4 in the range of 10-1000 pg/ml was detected in 18 out of 60 patients with SS (30%). Distinctive features of this group of patients were a shorter duration of the disease, progression of skin fibrosis and visceral pathology by the time of the examination, and a tendency towards a higher incidence of pulmonary fibrosis. Significant differences in the damage to other internal organs, as well as the dependence of the content of IL-4 on the clinical forms and course of the disease, were not revealed. In patients with an increase in IL-4 in the blood, higher levels of CIC, γ-globulins were noted, while the content of acute phase reactants was lower than in the rest of the group. Output. The established relationship between the serum level of IL-4 and the activity of the fibrous process in SS requires confirmation in prospective studies.

Keywords

Interleukin-4. T Lymphocytes, Fibrosis, Activity, Systemic Scleroderma