EFFECTS OF GOSSITAN AND GETASAN ON LIPID PEROXIDATION AND HIGH-PERMEABILITY PORE OF LIVER MITOCHONDRIA IN TOXIC HEPATITIS
In this study, the effect of gossitan and hetasan polyphenols on lipid peroxidation (LPO) process of rat liver mitochondria and Ca2+ ion-mediated mitochondrial inhibition under conditions of CCl4-induced toxic hepatitis was investigated. To induce experimental toxic hepatitis in experimental rats, animals were injected subcutaneously with a 50% solution of CCl4 (0.5 ml/kg) once every 3 days. Toxic hepatitis induced rats were administered per os from gossitan, getasan polyphenols and quercetin flavonoids once a day for 20 days. Gossitan and getasan inhibited Fe2+/citrate-induced LPO in rat liver mitochondrial membrane under toxic hepatitis conditions, reduced malondialdehyde (MDA) content, and exhibited membrane-stabilizing effects. Gossitan and getasan polyphenols inhibit the open conformational state of mPTP (Mitochondrial permeability transition pore) of rat liver mitochondria in CCl4-induced toxic hepatitis.
Liver, Mitochondria, mPTP, CCl4, Fe2+/citrate, Gossitan, Getasan, Quercetin